منابع مشابه
Update on microbicide research and development-seeking new HIV prevention tools for women
Women and girls are especially vulnerable to HIV infection in sub-Saharan Africa, and in some of those countries, prevalence among young women can be up to 3 times higher than among men of the same age. Effective HIV prevention options for women are clearly needed in this setting. Several ARV-based vaginal microbicides are currently in development for prevention of HIV transmission to women and...
متن کاملRectal microbicide development.
The last few years have seen important progress in demonstrating the efficacy of oral pre-exposure prophylaxis, vaginal microbicides, and treatment as prevention as effective strategies for reducing the risk of acquiring or transmitting HIV infection. There has also been significant progress in the development of rectal microbicides. Preclinical non-human primate studies have demonstrated that ...
متن کاملMicrobicide dosage forms.
Microbicides are topically applied, user controlled dosage forms that are being developed to prevent the transmission of HIV during coitus. Early candidates focused on coitally dependent dosage forms such as gels and creams. More recent development has focused on broadening the coitally dependent options through the introduction of films and fast dissolving tablets. Additionally, it has become ...
متن کاملProteases commit microbicide
Proteases commit microbicide hite blood cells use proteases to kill their targets, according to new results from Emer Reeves, Hiu Lu, Anthony Segal (University College, London, England), and colleagues. The findings contradict previously accepted notions that reactive oxygen species (ROSs) are the killing agents. ROSs like superoxide are produced by NADPH oxidase activity when white blood cells...
متن کاملUnderstanding microbicide acceptability
In July 2010, the CAPRISA 004 trial demonstrated that a vaginal microbicide gel containing the antiretroviral drug tenofovir, reduced the risk of HIV infection for women by 39%. A confirmatory trial, FACTS 001, is ongoing in South Africa. If tenofovir microbicide gel is proven to reduce the risk of HIV acquisition, it could be available as an additional HIV prevention option for women in the fo...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2006
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.061124